Referenties:
JureidiniJ,McHenryL B.The illusion of evidence based medicineBMJ2022;376:o702doi:10.1136/bmj.o702
Hanin, L. Why statistical inference from clinical trials is likely to generate false and irreproducible results.BMC Med Res Methodol17, 127 (2017). https://doi.org/10.1186/s12874-017-0399-0
Hunyady J. The Result of Vitamin C Treatment of Patients with Cancer: Conditions Influencing the Effectiveness. Int J Mol Sci. 2022 Apr 15;23(8):4380. doi: 10.3390/ijms23084380. PMID: 35457200; PMCID: PMC9030840.
Marrs C, Lonsdale D. Hiding in Plain Sight: Modern Thiamine Deficiency.Cells. 2021; 10(10):2595. https://doi.org/10.3390/cells10102595
Jonus HC, Byrnes CC, Kim J, Valle ML, Bartlett MG, Said HM, Zastre JA. Thiamine mimetics sulbutiamine and benfotiamine as a nutraceutical approach to anticancer therapy. Biomed Pharmacother. 2020 Jan;121:109648. doi: 10.1016/j.biopha.2019.109648. Epub 2019 Nov 25. PMID: 31810115.
Park J, Hosomi K, Kawashima H, Chen YA, Mohsen A, Ohno H, Konishi K, Tanisawa K, Kifushi M, Kogawa M, Takeyama H, Murakami H, Kubota T, Miyachi M, Kunisawa J, Mizuguchi K. Dietary Vitamin B1 Intake Influences Gut Microbial Community and the Consequent Production of Short-Chain Fatty Acids. Nutrients. 2022 May 16;14(10):2078. doi: 10.3390/nu14102078. PMID: 35631219; PMCID: PMC9147846.
Argano C, Mallaci Bocchio R, Natoli G, Scibetta S, Lo Monaco M, Corrao S. Protective Effect of Vitamin D Supplementation on COVID-19-Related Intensive Care Hospitalization and Mortality: Definitive Evidence from Meta-Analysis and Trial Sequential Analysis. Pharmaceuticals (Basel). 2023 Jan 16;16(1):130. doi: 10.3390/ph16010130. PMID: 36678627; PMCID: PMC9864223.
Varikasuvu SR, Thangappazham B, Vykunta A, Duggina P, Manne M, Raj H, Aloori S. COVID-19 and vitamin D (Co-VIVID study): a systematic review and meta-analysis of randomized controlled trials. Expert Rev Anti Infect Ther. 2022 Jun;20(6):907-913. doi: 10.1080/14787210.2022.2035217. Epub 2022 Feb 3. PMID: 35086394; PMCID: PMC8862170.
Pan HC, Sheu ML, Su HL, Chen YJ, Chen CJ, Yang DY, Chiu WT, Cheng FC. Magnesium supplement promotes sciatic nerve regeneration and down-regulates inflammatory response. Magnes Res. 2011 Jun;24(2):54-70. doi: 10.1684/mrh.2011.0280. PMID: 21609904.
Zhang J, Zhang B, Zhang J, Lin W, Zhang S. Magnesium Promotes the Regeneration of the Peripheral Nerve. Front Cell Dev Biol. 2021 Aug 11;9:717854. doi: 10.3389/fcell.2021.717854. PMID: 34458271; PMCID: PMC8385315.
Kodentsova VM, Zhilinskaya NV, Salagay OO, Tutelyan VA. [Specialized vitamin-mineral supplements for persons in extreme conditions]. Vopr Pitan. 2022;91(6):6-16. Russian. doi: 10.33029/0042-8833-2022-91-6-6-16. Epub 2022 Oct 10. PMID: 36648178.
Cuciureanu MD, Vink R. Magnesium and stress. In: Vink R, Nechifor M, editors. Magnesium in the Central Nervous System [Internet]. Adelaide (AU): University of Adelaide Press; 2011.Available from: https://www.ncbi.nlm.nih.gov/books/NBK507250/
Eby GA, Eby KL. Rapid recovery from major depression using magnesium treatment. Med Hypotheses. 2006;67(2):362-70. doi: 10.1016/j.mehy.2006.01.047. Epub 2006 Mar 20. PMID: 16542786.
Gesch CB, Hammond SM, Hampson SE, Eves A, Crowder MJ. Influence of supplementary vitamins, minerals and essential fatty acids on the antisocial behaviour of young adult prisoners. Randomised, placebo-controlled trial. Br J Psychiatry. 2002 Jul;181:22-8. doi: 10.1192/bjp.181.1.22. PMID: 12091259.
Schoenthaler SJ, Bier ID. The effect of vitamin-mineral supplementation on juvenile delinquency among American schoolchildren: a randomized, double-blind placebo-controlled trial. J Altern Complement Med. 2000 Feb;6(1):7-17. doi: 10.1089/acm.2000.6.7. PMID: 10706231.
Zdzieblik D, Jendricke P, Oesser S, Gollhofer A, König D. The Influence of Specific Bioactive Collagen Peptides on Body Composition and Muscle Strength in Middle-Aged, Untrained Men: A Randomized Controlled Trial. Int J Environ Res Public Health. 2021 Apr 30;18(9):4837. doi: 10.3390/ijerph18094837. PMID: 33946565; PMCID: PMC8125453.
Leidig-Bruckner G, Roth HJ, Bruckner T, Lorenz A, Raue F, Frank-Raue K. Are commonly recommended dosages for vitamin D supplementation too low? Vitamin D status and effects of supplementation on serum 25-hydroxyvitamin D levels–an observational study during clinical practice conditions. Osteoporos Int. 2011 Jan;22(1):231-40. doi: 10.1007/s00198-010-1214-5. Epub 2010 Jun 17. PMID: 20556359.
Noriega-González DC, Drobnic F, Caballero-García A, Roche E, Perez-Valdecantos D, Córdova A. Effect of Vitamin C on Tendinopathy Recovery: A Scoping Review. Nutrients. 2022 Jun 27;14(13):2663. doi: 10.3390/nu14132663. PMID: 35807843; PMCID: PMC9267994.
Feehan O, Armstrong DJ, Magee PJ, Pourshahidi KL, Strain JJ, Beggan L, Cobice DF, McSorley EM. Vitamin D and Bone Health of Older Adults within Care Homes: An Observational Study. Nutrients. 2022 Jun 28;14(13):2680. doi: 10.3390/nu14132680. PMID: 35807859; PMCID: PMC9268702.
Khatri M, Naughton RJ, Clifford T, Harper LD, Corr L. The effects of collagen peptide supplementation on body composition, collagen synthesis, and recovery from joint injury and exercise: a systematic review. Amino Acids. 2021 Oct;53(10):1493-1506. doi: 10.1007/s00726-021-03072-x. Epub 2021 Sep 7. PMID: 34491424; PMCID: PMC8521576.
Kirmse M, Oertzen-Hagemann V, de Marées M, Bloch W, Platen P. Prolonged Collagen Peptide Supplementation and Resistance Exercise Training Affects Body Composition in Recreationally Active Men. Nutrients. 2019 May 23;11(5):1154. doi: 10.3390/nu11051154. PMID: 31126103; PMCID: PMC6566878.
Kjaer M, Frederiksen AKS, Nissen NI, Willumsen N, van Hall G, Jorgensen LN, Andersen JR, Ågren MS. Multinutrient Supplementation Increases Collagen Synthesis during Early Wound Repair in a Randomized Controlled Trial in Patients with Inguinal Hernia. J Nutr. 2020 Apr 1;150(4):792-799. doi: 10.1093/jn/nxz324. PMID: 31897483.
Ellinger S, Stehle P. Efficacy of vitamin supplementation in situations with wound healing disorders: results from clinical intervention studies. Curr Opin Clin Nutr Metab Care. 2009 Nov;12(6):588-95. doi: 10.1097/MCO.0b013e328331a5b5. PMID: 19770648.
Desneves KJ, Todorovic BE, Cassar A, Crowe TC. Treatment with supplementary arginine, vitamin C and zinc in patients with pressure ulcers: a randomised controlled trial. Clin Nutr. 2005 Dec;24(6):979-87. doi: 10.1016/j.clnu.2005.06.011. Epub 2005 Nov 15. PMID: 16297506.
Pullar JM, Carr AC, Vissers MCM. The Roles of Vitamin C in Skin Health. Nutrients. 2017 Aug 12;9(8):866. doi: 10.3390/nu9080866. PMID: 28805671; PMCID: PMC5579659.
Ravindran P, Wiltshire S, Das K, Wilson RB. Vitamin C deficiency in an Australian cohort of metropolitan surgical patients. Pathology. 2018 Oct;50(6):654-658. doi: 10.1016/j.pathol.2018.07.004. Epub 2018 Aug 31. Erratum in: Pathology. 2018 Dec;50(7):793. PMID: 30177219.
Gunton JE, Girgis CM, Lau T, Vicaretti M, Begg L, Flood V. Vitamin C improves healing of foot ulcers: a randomised, double-blind, placebo-controlled trial. Br J Nutr. 2021 Nov 28;126(10):1451-1458. doi: 10.1017/S0007114520003815. Epub 2020 Sep 28. PMID: 32981536.
Bechara N, Flood VM, Gunton JE. A Systematic Review on the Role of Vitamin C in Tissue Healing. Antioxidants (Basel). 2022 Aug 19;11(8):1605. doi: 10.3390/antiox11081605. PMID: 36009324; PMCID: PMC9405326.
Kviatkovsky SA, Hickner RC, Ormsbee MJ. Collagen peptide supplementation for pain and function: is it effective and if so, why? Curr Opin Clin Nutr Metab Care. 2022 Sep 1. doi: 10.1097/MCO.0000000000000870. Epub ahead of print. PMID: 36044324.
Macian N, Dualé C, Voute M, Leray V, Courrent M, Bodé P, Giron F, Sonneville S, Bernard L, Joanny F, Menard K, Ducheix G, Pereira B, Pickering G. Short-Term Magnesium Therapy Alleviates Moderate Stress in Patients with Fibromyalgia: A Randomized Double-Blind Clinical Trial. Nutrients. 2022 May 17;14(10):2088. doi: 10.3390/nu14102088. PMID: 35631229; PMCID: PMC9145501.
McMullin PR, Hynes AT, Arefin MA, Saeed M, Gandhavadi S, Arefin N, Eckmann MS. Infusion Therapy in the Treatment of Neuropathic Pain. Curr Pain Headache Rep. 2022 Jul 6. doi: 10.1007/s11916-022-01071-5. Epub ahead of print. PMID: 35794449.
Sohn HM, Ahn H, Seo WS, Yi IK, Park JY. Magnesium Sulfate and Cerebral Oxygen Saturation in Mild Traumatic Brain Injury: A Randomized, Double-Blind, Controlled Trial. J Clin Med. 2022 Jun 13;11(12):3388. doi: 10.3390/jcm11123388. PMID: 35743456; PMCID: PMC9225065.
Derbel R, Achour I, Thabet W, Chakroun A, Zouch I, Charfeddine I. Addition of magnesium sulfate to bupivacaine improves analgesic efficacy after tonsillectomy: A randomized trial and a CONSORT analysis. Eur Ann Otorhinolaryngol Head Neck Dis. 2022 Jun 7:S1879-7296(22)00059-X. doi: 10.1016/j.anorl.2022.04.007. Epub ahead of print. PMID: 35688677.
Matin H, Taghian F, Chitsaz A. Artificial intelligence analysis to explore synchronize exercise, cobalamin, and magnesium as new actors to therapeutic of migraine symptoms: a randomized, placebo-controlled trial. Neurol Sci. 2022 Jul;43(7):4413-4424. doi: 10.1007/s10072-021-05843-6. Epub 2022 Feb 3. PMID: 35112219.
Kakehashi T, Obayashi M, Watanabe J. Appraisal of intravenous magnesium sulfate vs. morphine sulfate in relieving renal colic: A randomized clinical trial. Am J Emerg Med. 2022 Jul;57:174. doi: 10.1016/j.ajem.2021.12.018. Epub 2021 Dec 15. PMID: 34949475.
Kulik K, Żyżyńska-Granica B, Kowalczyk A, Kurowski P, Gajewska M, Bujalska-Zadrożny M. Magnesium and Morphine in the Treatment of Chronic Neuropathic Pain-A Biomedical Mechanism of Action. Int J Mol Sci. 2021 Dec 18;22(24):13599. doi: 10.3390/ijms222413599. PMID: 34948397; PMCID: PMC8707930.
Choi GJ, Kim YI, Koo YH, Oh HC, Kang H. Perioperative Magnesium for Postoperative Analgesia: An Umbrella Review of Systematic Reviews and Updated Meta-Analysis of Randomized Controlled Trials. J Pers Med. 2021 Dec 2;11(12):1273. doi: 10.3390/jpm11121273. PMID: 34945745; PMCID: PMC8708823.
Zhang J, Mai CL, Xiong Y, Lin ZJ, Jie YT, Mai JZ, Liu C, Xie MX, Zhou X, Liu XG. The Causal Role of Magnesium Deficiency in the Neuroinflammation, Pain Hypersensitivity and Memory/Emotional Deficits in Ovariectomized and Aged Female Mice. J Inflamm Res. 2021 Dec 7;14:6633-6656. doi: 10.2147/JIR.S330894. PMID: 34908863; PMCID: PMC8665878.
Barna O, Lohoida P, Holovchenko Y, Bazylevych A, Velychko V, Hovbakh I, Bula L, Shechter M. A randomized, double-blind, placebo-controlled, multicenter study assessing the efficacy of magnesium oxide monohydrate in the treatment of nocturnal leg cramps. Nutr J. 2021 Oct 31;20(1):90. doi: 10.1186/s12937-021-00747-9. PMID: 34719399; PMCID: PMC8559389.
Sohn HM, Kim BY, Bae YK, Seo WS, Jeon YT. Magnesium Sulfate Enables Patient Immobilization during Moderate Block and Ameliorates the Pain and Analgesic Requirements in Spine Surgery, Which Can Not Be Achieved with Opioid-Only Protocol: A Randomized Double-Blind Placebo-Controlled Study. J Clin Med. 2021 Sep 22;10(19):4289. doi: 10.3390/jcm10194289. PMID: 34640307; PMCID: PMC8509453.
Park JW, Kim EK, Lee J, Chung SH, Boo G, Do SH. Effect of Intraoperative Magnesium Sulfate Administration on Blood Glucose Control following Total Joint Arthroplasty in Patients with Diabetes. J Clin Med. 2022 May 27;11(11):3040. doi: 10.3390/jcm11113040. PMID: 35683428; PMCID: PMC9181658.
Macian N, Dualé C, Voute M, Leray V, Courrent M, Bodé P, Giron F, Sonneville S, Bernard L, Joanny F, Menard K, Ducheix G, Pereira B, Pickering G. Short-Term Magnesium Therapy Alleviates Moderate Stress in Patients with Fibromyalgia: A Randomized Double-Blind Clinical Trial. Nutrients. 2022 May 17;14(10):2088. doi: 10.3390/nu14102088. PMID: 35631229; PMCID: PMC9145501.
Noah L, Morel V, Bertin C, Pouteau E, Macian N, Dualé C, Pereira B, Pickering G. Effect of a Combination of Magnesium, B Vitamins, Rhodiola, and Green Tea (L-Theanine) on Chronically Stressed Healthy Individuals-A Randomized, Placebo-Controlled Study. Nutrients. 2022 Apr 29;14(9):1863. doi: 10.3390/nu14091863. PMID: 35565828; PMCID: PMC9102162.
Kamel AAF, Medhat MM, Salem DAE, Naby SMA. Effect of perioperative magnesium sulfate and labetalol infusion on peripheral perfusion and postoperative pain in nasal surgery: a randomized controlled trial. Patient Saf Surg. 2022 Aug 19;16(1):27. doi: 10.1186/s13037-022-00336-7. PMID: 35986325; PMCID: PMC9392252.
Leitch J, Webb A, Pudwell J, Chamberlain S, Henry R, Nitsch R. Magnesium-Based Trigger Point Infiltrations Versus Local Anaesthetic Infiltrations in Chronic Pelvic Myofascial Pain: A Randomized, Double-Blind, Controlled Study. J Obstet Gynaecol Can. 2022 Aug;44(8):877-885. doi: 10.1016/j.jogc.2022.02.129. Epub 2022 Mar 24. PMID: 35339694.
Yazdi AP, Esmaeeli M, Gilani MT. Effect of intravenous magnesium on postoperative pain control for major abdominal surgery: a randomized double-blinded study. Anesth Pain Med (Seoul). 2022 Jul;17(3):280-285. doi: 10.17085/apm.22156. Epub 2022 Jul 28. PMID: 35918860; PMCID: PMC9346203.
Fathy W, Hussein M, Ibrahim RE, Abdel-Aziz MM, Adel S, Soliman SH, Elmoutaz H, Abdelkader M. Comparative effect of transforaminal injection of Magnesium sulphate versus Ozone on oxidative stress biomarkers in lumbar disc related radicular pain. BMC Anesthesiol. 2022 Aug 8;22(1):254. doi: 10.1186/s12871-022-01789-0. PMID: 35941548; PMCID: PMC9358797.
Bahrampour N, Clark CCT. The relationship between dietary acid load and intensity of musculoskeletal pain condition: A population-based study. Food Sci Nutr. 2022 Apr 5;10(8):2542-2549. doi: 10.1002/fsn3.2859. PMID: 35959275; PMCID: PMC9361435.
Bahrampour N, Rasaei N, Gholami F, Clark CCT. The Association Between Dietary Energy Density and Musculoskeletal Pain in Adult Men and Women. Clin Nutr Res. 2022 Apr 26;11(2):110-119. doi: 10.7762/cnr.2022.11.2.110. PMID: 35559001; PMCID: PMC9065393.
Heath AK, Muller DC, van den Brandt PA, Critselis E, Gunter M, Vineis P, Weiderpass E, Boeing H, Ferrari P, Merritt MA, Rostgaard-Hansen AL, Tjønneland A, Overvad K, Katzke V, Srour B, Masala G, Sacerdote C, Ricceri F, Pasanisi F, Bueno-de-Mesquita B, Downward GS, Skeie G, Sandanger TM, Crous-Bou M, Rodríguez-Barranco M, Amiano P, Huerta JM, Ardanaz E, Drake I, Johansson M, Johansson I, Key T, Papadimitriou N, Riboli E, Tzoulaki I, Tsilidis KK. Diet-wide association study of 92 foods and nutrients and lung cancer risk in the European Prospective Investigation into Cancer and Nutrition study and the Netherlands Cohort Study. Int J Cancer. 2022 Jul 13. doi: 10.1002/ijc.34211. Epub ahead of print. PMID: 35830197.
El Driny WA, Esmat IM, Shaheen SM, Sabri NA. Efficacy of High-Dose Vitamin C Infusion on Outcomes in Sepsis Requiring Mechanical Ventilation: A Double-Blind Randomized Controlled Trial. Anesthesiol Res Pract. 2022 Jul 15;2022:4057215. doi: 10.1155/2022/4057215. PMID: 35873893; PMCID: PMC9307402.
Tang X, Liu H, Xiao Y, Wu L, Shu P. Vitamin C Intake and Ischemic Stroke. Front Nutr. 2022 Jul 14;9:935991. doi: 10.3389/fnut.2022.935991. PMID: 35911106; PMCID: PMC9330473.
Honore PM, Blackman S, Bousbiat I, Perriens E, Attou R. Up to 100 g of Intravenous Vitamin C Appears to be Safe and Elicits No Adverse Effects but Needs Further Evaluation in High-Risk Groups. Clin Pharmacokinet. 2022 Jul 30. doi: 10.1007/s40262-022-01156-9. Epub ahead of print. PMID: 35908007.
Park SK, Chung Y, Oh CM, Ryoo JH, Jung JY. The influence of dietary intake of vitamin C and vitamin E on the risk of gastric intestinal metaplasia. Epidemiol Health. 2022 Jul 29:e2022062. doi: 10.4178/epih.e2022062. Epub ahead of print. PMID: 35914770.
Jankowski CSR, Rabinowitz JD. Selenium modulates cancer cell response to pharmacologic ascorbate. Cancer Res. 2022 Aug 2:CAN-22-0408. doi: 10.1158/0008-5472.CAN-22-0408. Epub ahead of print. PMID: 35916672.
Nikooseresht M, Hajian P, Moradi A, Sanatkar M. Evaluation of the Effects of Oral Magnesium Sachet on the Prevention of Spinal Anesthesia-Induced Headache After Cesarean Section: A Randomized Clinical Trial. Anesth Pain Med. 2022 Mar 22;12(1):e121834. doi: 10.5812/aapm.121834. PMID: 35433384; PMCID: PMC8995875.
Rossi RE, Chen J, Caplin ME. The Role of Diet and Supplements in the Prevention and Progression of COVID-19: Current Knowledge and Open Issues. Prev Nutr Food Sci. 2022 Jun 30;27(2):137-149. doi: 10.3746/pnf.2022.27.2.137. PMID: 35919576; PMCID: PMC9309075.
Schöller A, Géraud C. Hautveränderungen bei Vitamin- und Mineralstoffmangel [Dermatologic manifestations of vitamin and mineral deficiency]. Dermatologie (Heidelb). 2022 Aug;73(8):647-655. German. doi: 10.1007/s00105-022-05029-x. Epub 2022 Jul 14. PMID: 35925237.
Luo X, Ng C, He J, Yang M, Luo X, Herbert TP, Whitehead JP. Vitamin C protects against hypoxia, inflammation, and ER stress in primary human preadipocytes and adipocytes. Mol Cell Endocrinol. 2022 Aug 4;556:111740. doi: 10.1016/j.mce.2022.111740. Epub ahead of print. PMID: 35932980.
Bhowmik KK, Barek MA, Aziz MA, Islam MS. Impact of high-dose vitamin C on the mortality, severity, and duration of hospital stay in COVID-19 patients: A meta-analysis. Health Sci Rep. 2022 Aug 8;5(5):e762. doi: 10.1002/hsr2.762. PMID: 35949675; PMCID: PMC9358542.
Zhu H, Xu X, Zhang K, Ye Q. The effect of intravenous vitamin C on clinical outcomes in patients with sepsis or septic shock: A meta-analysis of randomized controlled trials. Front Nutr. 2022 Jul 28;9:964484. doi: 10.3389/fnut.2022.964484. PMID: 35967816; PMCID: PMC9366349.
Zhang W, Jiang J, He Y, Li X, Yin S, Chen F, Li W. Association between vitamins and risk of brain tumors: A systematic review and dose-response meta-analysis of observational studies. Front Nutr. 2022 Jul 29;9:935706. doi: 10.3389/fnut.2022.935706. PMID: 35967781; PMCID: PMC9372437.
Al-Hayder MN, Aledani THW, Al-Mayyahi RS. Amelioration of the hepatotoxic effects of nonsteroidal drugs using vitamin C and determination of their relationship with the lipid profile. J Taibah Univ Med Sci. 2021 Dec 13;17(4):715-723. doi: 10.1016/j.jtumed.2021.11.003. PMID: 35983440; PMCID: PMC9356344.
Larsson SC, Mason AM, Vithayathil M, Carter P, Kar S, Zheng JS, Burgess S. Circulating vitamin C and digestive system cancers: Mendelian randomization study. Clin Nutr. 2022 Aug 7;41(9):2031-2035. doi: 10.1016/j.clnu.2022.07.040. Epub ahead of print. PMID: 35986965.
Rozemeijer S, de Grooth HJ, Elbers PWG, Girbes ARJ, den Uil CA, Dubois EA, Wils EJ, Rettig TCD, van Zanten ARH, Vink R, van den Bogaard B, Bosman RJ, Oudemans-van Straaten HM, de Man AME. Early high-dose vitamin C in post-cardiac arrest syndrome (VITaCCA): study protocol for a randomized, double-blind, multi-center, placebo-controlled trial. Trials. 2021 Aug 18;22(1):546. doi: 10.1186/s13063-021-05483-3. PMID: 34407846; PMCID: PMC8371424.
Böttger F, Vallés-Martí A, Cahn L, Jimenez CR. High-dose intravenous vitamin C, a promising multi-targeting agent in the treatment of cancer. J Exp Clin Cancer Res. 2021 Oct 30;40(1):343. doi: 10.1186/s13046-021-02134-y. PMID: 34717701; PMCID: PMC8557029.
Boretti A, Banik BK. Intravenous Vitamin C for reduction of cytokines storm in Acute Respiratory Distress Syndrome [published online ahead of print, 2020 Apr 21].PharmaNutrition. 2020;12:100190. doi:10.1016/j.phanu.2020.100190
Grant WB, Lahore H, McDonnell SL, Baggerly CA, French CB, Aliano JL, BhattoaHP. Evidence that Vitamin D Supplementation Could Reduce Risk of Influenza andCOVID-19 Infections and Deaths. Nutrients. 2020 Apr 2;12(4). pii: E988. doi:10.3390/nu12040988. Review. PubMed PMID: 32252338.
Martineau AR, Jolliffe DA, Greenberg L, et al. Vitamin D supplementation to prevent acute respiratory infections: individual participant data meta-analysis.Health Technol Assess. 2019;23(2):1–44. doi:10.3310/hta23020
Prietl B, Treiber G, Pieber TR, Amrein K. Vitamin D and immune function.Nutrients. 2013;5(7):2502–2521. Published 2013 Jul 5. doi:10.3390/nu5072502
Medrano M, Carrillo-Cruz E, Montero I, Perez-Simon JA. Vitamin D: Effect on Haematopoiesis and Immune System and Clinical Applications.Int J Mol Sci. 2018;19(9):2663. Published 2018 Sep 8. doi:10.3390/ijms19092663
Bitetto D, Fabris C, Fornasiere E, et al. Vitamin D supplementation improves response to antiviral treatment for recurrent hepatitis C.Transpl Int. 2011;24(1):43–50. doi:10.1111/j.1432-2277.2010.01141.x
Yokoyama S, Takahashi S, Kawakami Y, et al. Effect of vitamin D supplementation on pegylated interferon/ribavirin therapy for chronic hepatitis C genotype 1b: a randomized controlled trial.J Viral Hepat. 2014;21(5):348–356. doi:10.1111/jvh.12146
Coelho L, Cardoso SW, Luz PM, et al. Vitamin D3 supplementation in HIV infection: effectiveness and associations with antiretroviral therapy.Nutr J. 2015;14:81. Published 2015 Aug 18. doi:10.1186/s12937-015-0072-6
Saper RB, Rash R. Zinc: an essential micronutrient.Am Fam Physician. 2009;79(9):768–772.
Barnett JB, Hamer DH, Meydani SN. Low zinc status: a new risk factor for pneumonia in the elderly?.Nutr Rev. 2010;68(1):30–37. doi:10.1111/j.1753-4887.2009.00253.x
Wessels I, Maywald M, Rink L. Zinc as a Gatekeeper of Immune Function.Nutrients. 2017;9(12):1286. Published 2017 Nov 25. doi:10.3390/nu9121286
Prasad AS. Zinc: role in immunity, oxidative stress and chronic inflammation.Curr Opin Clin Nutr Metab Care. 2009;12(6):646–652. doi:10.1097/MCO.0b013e3283312956
Martinez-Estevez NS, Alvarez-Guevara AN, Rodriguez-Martinez CE. Effects of zinc supplementation in the prevention of respiratory tract infections and diarrheal disease in Colombian children: A 12-month randomised controlled trial.Allergol Immunopathol (Madr). 2016;44(4):368–375. doi:10.1016/j.aller.2015.12.006
Rerksuppaphol S, Rerksuppaphol L. A randomized controlled trial of zinc supplementation in the treatment of acute respiratory tract infection in Thai children.Pediatr Rep. 2019;11(2):7954. Published 2019 May 23. doi:10.4081/pr.2019.7954
Hemilä H. Zinc lozenges and the common cold: a meta-analysis comparing zinc acetate and zinc gluconate, and the role of zinc dosage.JRSM Open. 2017;8(5):2054270417694291. Published 2017 May 2. doi:10.1177/2054270417694291
Liguori I, Russo G, Curcio F, et al. Oxidative stress, aging, and diseases.Clin Interv Aging. 2018;13:757–772. Published 2018 Apr 26. doi:10.2147/CIA.S158513
Carr AC, Maggini S. Vitamin C and Immune Function.Nutrients. 2017;9(11):1211. Published 2017 Nov 3. doi:10.3390/nu9111211
Hemilä H, Chalker E. Vitamin C for preventing and treating the common cold.Cochrane Database Syst Rev. 2013;(1):CD000980. Published 2013 Jan 31. doi:10.1002/14651858.CD000980.pub4
Bucher A, White N. Vitamin C in the Prevention and Treatment of the Common Cold.Am J Lifestyle Med. 2016;10(3):181–183. Published 2016 Feb 9. doi:10.1177/1559827616629092
Li J. Evidence is stronger than you think: a meta-analysis of vitamin C use in patients with sepsis.Crit Care. 2018;22(1):258. Published 2018 Oct 11. doi:10.1186/s13054-018-2191-x
Fowler Iii AA, Kim C, Lepler L, et al. Intravenous vitamin C as adjunctive therapy for enterovirus/rhinovirus induced acute respiratory distress syndrome.World J Crit Care Med. 2017;6(1):85–90. Published 2017 Feb 4. doi:10.5492/wjccm.v6.i1.85
Maggini S, Pierre A, Calder PC. Immune Function and Micronutrient Requirements Change over the Life Course.Nutrients. 2018;10(10):1531. Published 2018 Oct 17. doi:10.3390/nu10101531
Ali A, Njike VY, Northrup V, Sabina AB, Williams AL, Liberti LS, Perlman AI,Adelson H, Katz DL. Intravenous micronutrient therapy (Myers' Cocktail) forfibromyalgia: a placebo-controlled pilot study. J Altern Complement Med. 2009Mar;15(3):247-57. doi: 10.1089/acm.2008.0410. PubMed PMID: 19250003; PubMedCentral PMCID: PMC2894814.
Forman HJ, Zhang H, Rinna A. Glutathione: overview of its protective roles,measurement, and biosynthesis. Mol Aspects Med. 2009 Feb-Apr;30(1-2):1-12. doi:10.1016/j.mam.2008.08.006. Epub 2008 Aug 30. Review. PubMed PMID: 18796312;PubMed Central PMCID: PMC2696075.
Schulz JB, Lindenau J, Seyfried J, Dichgans J. Glutathione, oxidative stressand neurodegeneration. Eur J Biochem. 2000 Aug;267(16):4904-11. Review. PubMedPMID: 10931172.
Viña J, Gomez-Cabrera MC, Lloret A, Marquez R, Miñana JB, Pallardó FV, Sastre J. Free radicals in exhaustive physical exercise: mechanism of production, andprotection by antioxidants. IUBMB Life. 2000 Oct-Nov;50(4-5):271-7. Review.PubMed PMID: 11327321.
Reed JC. Magnesium therapy in musculoskeletal pain syndromes — retrospective review of clinical results.Magnes Trace Elem1990;9:330.
Shealy CN, Cady RK, Veehoff D, et al. Magnesium deficiency in depression and chronic pain.Magnes Trace Elem1990;9:333.
Plotnikoff GA, Quigley JM. Prevalence of severe hypovitaminosis D in patients with persistent, nonspecific musculoskeletal pain. Mayo Clin Proc. 2003Dec;78(12):1463-70. PubMed PMID: 14661675.
Snyder PJ, Bhasin S, Cunningham GR, Matsumoto AM, Stephens-Shields AJ, Cauley JA, Gill TM, Barrett-Connor E, Swerdloff RS, Wang C, Ensrud KE, Lewis CE, Farrar JT, Cella D, Rosen RC, Pahor M, Crandall JP, Molitch ME, Cifelli D, Dougar D,Fluharty L, Resnick SM, Storer TW, Anton S, Basaria S, Diem SJ, Hou X, Mohler ER 3rd, Parsons JK, Wenger NK, Zeldow B, Landis JR, Ellenberg SS; TestosteroneTrials Investigators.. Effects of Testosterone Treatment in Older Men. N Engl JMed. 2016 Feb 18;374(7):611-24. doi: 10.1056/NEJMoa1506119. PubMed PMID:26886521.
van Leeuwen R, Boekhoorn S, Vingerling JR, Witteman JC, Klaver CC, Hofman A,de Jong PT. Dietary intake of antioxidants and risk of age-related maculardegeneration. JAMA. 2005 Dec 28;294(24):3101-7. PubMed PMID: 16380590.
Knekt P, Ritz J, Pereira MA, O'Reilly EJ, Augustsson K, Fraser GE, GoldbourtU, Heitmann BL, Hallmans G, Liu S, Pietinen P, Spiegelman D, Stevens J, VirtamoJ, Willett WC, Rimm EB, Ascherio A. Antioxidant vitamins and coronary heartdisease risk: a pooled analysis of 9 cohorts. Am J Clin Nutr. 2004Dec;80(6):1508-20. PubMed PMID: 15585762.
Myint PK, Luben RN, Welch AA, Bingham SA, Wareham NJ, Khaw KT. Plasma vitamin C concentrations predict risk of incident stroke over 10 y in 20 649 participantsof the European Prospective Investigation into Cancer Norfolk prospectivepopulation study. Am J Clin Nutr. 2008 Jan;87(1):64-9. PubMed PMID: 18175738.
Steinbrenner H, Al-Quraishy S, Dkhil MA, Wunderlich F, Sies H. Dietary selenium in adjuvant therapy of viral and bacterial infections.Adv Nutr. 2015;6(1):73–82. Published 2015 Jan 15. doi:10.3945/an.114.007575
Lin Z, Li Y, Gong G, et al. Restriction of H1N1 influenza virus infection by selenium nanoparticles loaded with ribavirin via resisting caspase-3 apoptotic pathway.Int J Nanomedicine. 2018;13:5787–5797. Published 2018 Sep 26. doi:10.2147/IJN.S177658
Qian B, Shen S, Zhang J, Jing P. Effects of Vitamin B6 Deficiency on the Composition and Functional Potential of T Cell Populations.J Immunol Res. 2017;2017:2197975. doi:10.1155/2017/2197975
Case HS (2018) Vitamin C questions answered.Orthomolecular Medicine News Service,http://orthomolecular.org/resources/omns/v14n12.shtml.
Gonzalez MJ, Berdiel MJ, Duconge J (2018) High dose vitamin C and influenza: A case report.J Orthomol Med.June, 2018, 33(3).https://isom.ca/article/high-dose-vitamin-c-influenza-case-report.
Gorton HC, Jarvis K (1999) The effectiveness of vitamin C in preventing and relieving the symptoms of virus-induced respiratory infections.J Manip Physiol Ther, 22:8, 530-533.https://www.ncbi.nlm.nih.gov/pubmed/10543583
Hemilä H (2017) Vitamin C and infections.Nutrients. 9(4). pii:E339.https://www.ncbi.nlm.nih.gov/pubmed/28353648.
Hickey S, Saul AW (2015) Vitamin C: The real story.Basic Health Pub.ISBN-13: 978-1591202233.
Levy TE (2014) The clinical impact of vitamin C.Orthomolecular Medicine News Service,http://orthomolecular.org/resources/omns/v10n14.shtml
OMNS(2007) Vitamin C: a highly effective treatment for colds.http://orthomolecular.org/resources/omns/v03n05.shtml.
OMNS(2009) Vitamin C as an antiviralhttp://orthomolecular.org/resources/omns/v05n09.shtml.
Taylor T (2017) Vitamin C material: where to start, what to watch.OMNS,http://www.orthomolecular.org/resources/omns/v13n20.shtml.
Yejin Kim, Hyemin Kim, Seyeon Bae et al. (2013) Vitamin C is an essential factor on the anti-viral immune responses through the production of interferon-α/β at the initial stage of influenza A virus (H3N2) infection.Immune Netw.13:70-74.https://www.ncbi.nlm.nih.gov/pubmed/23700397.
Cannell JJ, Vieth R, Umhau JC et al. (2006) Epidemic influenza and vitamin D.Epidemiol Infect.134:1129-1140.https://www.ncbi.nlm.nih.gov/pubmed/16959053.
Cannell JJ, Zasloff M, Garland CF et al. (2008) On the epidemiology of influenza.Virol J.5:29.https://www.ncbi.nlm.nih.gov/pubmed/16959053.
Ginde AA, Mansbach JM, Camargo CA Jr. (2009) Association between serum 25-hydroxyvitamin D level and upper respiratory tract infection in the Third National Health and Nutrition Examination Survey.Arch Intern Med.169:384-390.https://www.ncbi.nlm.nih.gov/pubmed/19237723.
Martineau AR, Jolliffe DA, Hooper RL et al. (2017) Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data.BMJ.356:i6583.https://www.ncbi.nlm.nih.gov/pubmed/28202713.
Urashima M, Segawa T, Okazaki M et al. (2010) Randomized trial of vitamin D supplementation to prevent seasonal influenza A in schoolchildren.Am J Clin Nutr.91:1255-60.https://www.ncbi.nlm.nih.gov/pubmed/20219962.
von Essen MR, Kongsbak M, Schjerling P et al. (2010) Vitamin D controls T cell antigen receptor signaling and activation of human T cells.Nat Immunol.11:344-349.https://www.ncbi.nlm.nih.gov/pubmed/20208539.
Fraker PJ, King LE, Laakko T, Vollmer TL. (2000) The dynamic link between the integrity of the immune system and zinc status.J Nutr.130:1399S-406S.https://www.ncbi.nlm.nih.gov/pubmed/10801951.
Liu MJ, Bao S, Gálvez-Peralta M, et al. (2013) ZIP8 regulates host defense through zinc-mediated inhibition of NF-кB.Cell Rep.3:386-400.https://www.ncbi.nlm.nih.gov/pubmed/23403290.
Mocchegiani E, Muzzioli M. (2000) Therapeutic application of zinc in human immunodeficiency virus against opportunistic infections.J Nutr.130:1424S-1431S.https://www.ncbi.nlm.nih.gov/pubmed/10801955.
Shankar AH, Prasad AS. (1998) Zinc and immune function: the biological basis of altered resistance to infection.Am J Clin Nutr.68:447S-463S.https://www.ncbi.nlm.nih.gov/pubmed/9701160.
Beck MA, Levander OA, Handy J. (2003) Selenium deficiency and viral infection.J Nutr.133:1463S-1467S.https://www.ncbi.nlm.nih.gov/pubmed/12730444.
Hoffmann PR, Berry MJ. (2008) The influence of selenium on immune responses.Mol Nutr Food Res.52:1273-1280.https://www.ncbi.nlm.nih.gov/pubmed/18384097.
Steinbrenner H, Al-Quraishy S, Dkhil MA et al. (2015) Dietary selenium in adjuvant therapy of viral and bacterial infections.Adv Nutr.6:73-82.https://www.ncbi.nlm.nih.gov/pubmed/25593145.
Hemilä H, Chalker E. Vitamin C for preventing and treating the common cold.Cochrane Database Syst Rev. 2013 Jan 31;(1):CD000980. doi:10.1002/14651858.CD000980.pub4. Review. PubMed PMID: 23440782.
Righi NC, Schuch FB, De Nardi AT, Pippi CM, de Almeida Righi G, Puntel GO, da Silva AMV, Signori LU. Effects of vitamin C on oxidative stress, inflammation,muscle soreness, and strength following acute exercise: meta-analyses ofrandomized clinical trials. Eur J Nutr. 2020 Mar 11. doi:10.1007/s00394-020-02215-2. [Epub ahead of print] Review. PubMed PMID: 32162041.
Kim TK, Lim HR, Byun JS. Vitamin C supplementation reduces the odds ofdeveloping a common cold in Republic of Korea Army recruits: randomisedcontrolled trial. BMJ Mil Health. 2020 Mar 5. pii: bmjmilitary-2019-001384. doi: 10.1136/bmjmilitary-2019-001384. [Epub ahead of print] PubMed PMID: 32139409.Hawkins J, Baker C, Cherry L, Dunne E. Black elderberry (Sambucus nigra) supplementation effectively treats upper respiratory symptoms: A meta-analysis of randomized, controlled clinical trials.Complement Ther Med. 2019;42:361–365. doi:10.1016/j.ctim.2018.12.004
Hercberg S, Galan P, Preziosi P, Bertrais S, Mennen L, Malvy D, Roussel AM,Favier A, Briançon S. The SU.VI.MAX Study: a randomized, placebo-controlled trialof the health effects of antioxidant vitamins and minerals. Arch Intern Med. 2004Nov 22;164(21):2335-42. Erratum in: Arch Intern Med. 2005 Feb 14;165(3):286.PubMed PMID: 15557412.